ENSG00000128342


Homo sapiens

Features
Gene ID: ENSG00000128342
  
Biological name :LIF
  
Synonyms : LIF / LIF, interleukin 6 family cytokine / P15018
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.2
Gene start: 30240447
Gene end: 30246851
  
Corresponding Affymetrix probe sets: 205266_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000249075
Ensembl peptide - ENSP00000384450
NCBI entrez gene - 3976     See in Manteia.
OMIM - 159540
RefSeq - NM_001257135
RefSeq - NM_002309
RefSeq Peptide - NP_001244064
RefSeq Peptide - NP_002300
swissprot - P15018
Ensembl - ENSG00000128342
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIFENSGALG00000008028Gallus gallus
 LifENSMUSG00000034394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001581  Leukemia inhibitory factor /oncostatin
 IPR003624  Leukemia inhibitory factor
 IPR009079  Four-helical cytokine-like, core
 IPR019827  Leukemia inhibitory factor /oncostatin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IDA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0046888 negative regulation of hormone secretion IDA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048644 muscle organ morphogenesis IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway IDA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060426 lung vasculature development IEA
 biological_processGO:0060463 lung lobe morphogenesis IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060708 spongiotrophoblast differentiation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IDA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IDA
 biological_processGO:1901676 positive regulation of histone H3-K27 acetylation IDA
 biological_processGO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IC
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005146 leukemia inhibitory factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr