ENSG00000129691


Homo sapiens

Features
Gene ID: ENSG00000129691
  
Biological name :ASH2L
  
Synonyms : ASH2L / ASH2 like histone lysine methyltransferase complex subunit / Q9UBL3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.23
Gene start: 38105242
Gene end: 38144076
  
Corresponding Affymetrix probe sets: 209517_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430259
Ensembl peptide - ENSP00000429387
Ensembl peptide - ENSP00000430889
Ensembl peptide - ENSP00000443606
Ensembl peptide - ENSP00000340896
Ensembl peptide - ENSP00000395310
Ensembl peptide - ENSP00000427839
Ensembl peptide - ENSP00000428877
NCBI entrez gene - 9070     See in Manteia.
OMIM - 604782
RefSeq - XM_006716413
RefSeq - NM_001105214
RefSeq - NM_001261832
RefSeq - NM_001282272
RefSeq - NM_004674
RefSeq - XM_005273682
RefSeq - XM_005273683
RefSeq - XM_006716412
RefSeq Peptide - NP_001248761
RefSeq Peptide - NP_001269201
RefSeq Peptide - NP_004665
RefSeq Peptide - NP_001098684
swissprot - H0YBF6
swissprot - E5RFH5
swissprot - Q9UBL3
swissprot - E5RHM1
swissprot - F5H8F7
swissprot - H0YAQ0
Ensembl - ENSG00000129691
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ash2lENSDARG00000060392Danio rerio
 ASH2LENSGALG00000003233Gallus gallus
 Ash2lENSMUSG00000031575Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR037353  Histone methyltransferase complex subunit ASH2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0030097 hemopoiesis NAS
 biological_processGO:0043627 response to estrogen IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0035097 histone methyltransferase complex IPI
 cellular_componentGO:0044666 MLL3/4 complex IDA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990188 euchromatin binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
PKMTs methylate histone lysines
Deactivation of the beta-catenin transactivating complex
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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