ENSMUSG00000031575


Mus musculus

Features
Gene ID: ENSMUSG00000031575
  
Biological name :Ash2l
  
Synonyms : Ash2l / Mus musculus ASH2 like histone lysine methyltransferase complex subunit (Ash2l), transcript variant 4, mRNA. / Q91X20
  
Possible biological names infered from orthology : ASH2 like histone lysine methyltransferase complex subunit / Q9UBL3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25815996
Gene end: 25847694
  
Corresponding Affymetrix probe sets: 10577866 (MoGene1.0st)   1420615_at (Mouse Genome 430 2.0 Array)   1420616_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106239
Ensembl peptide - ENSMUSP00000106240
Ensembl peptide - ENSMUSP00000132546
Ensembl peptide - ENSMUSP00000118346
Ensembl peptide - ENSMUSP00000117488
Ensembl peptide - ENSMUSP00000070957
Ensembl peptide - ENSMUSP00000106238
NCBI entrez gene - 23808     See in Manteia.
MGI - MGI:1344416
RefSeq - XM_011242136
RefSeq - NM_001080793
RefSeq - NM_001286207
RefSeq - NM_001359012
RefSeq - NM_011791
RefSeq - XM_011242135
RefSeq Peptide - NP_001273136
RefSeq Peptide - NP_001074262
RefSeq Peptide - NP_001345941
RefSeq Peptide - NP_035921
swissprot - D3YYA0
swissprot - D6RI55
swissprot - E9PU93
swissprot - Q91X20
swissprot - D6RET1
Ensembl - ENSMUSG00000031575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ash2lENSDARG00000060392Danio rerio
 ASH2LENSGALG00000003233Gallus gallus
 ASH2LENSG00000129691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR037353  Histone methyltransferase complex subunit ASH2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048096 chromatin-mediated maintenance of transcription NAS
 biological_processGO:0051568 histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0044666 MLL3/4 complex IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0071339 MLL1 complex ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990188 euchromatin binding IDA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
PKMTs methylate histone lysines
Deactivation of the beta-catenin transactivating complex
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr