ENSG00000130177


Homo sapiens

Features
Gene ID: ENSG00000130177
  
Biological name :CDC16
  
Synonyms : CDC16 / cell division cycle 16 / Q13042
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 114234887
Gene end: 114272723
  
Corresponding Affymetrix probe sets: 202717_s_at (Human Genome U133 Plus 2.0 Array)   209658_at (Human Genome U133 Plus 2.0 Array)   209659_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364459
Ensembl peptide - ENSP00000364457
Ensembl peptide - ENSP00000486027
Ensembl peptide - ENSP00000252457
Ensembl peptide - ENSP00000252458
Ensembl peptide - ENSP00000348554
Ensembl peptide - ENSP00000353549
NCBI entrez gene - 8881     See in Manteia.
OMIM - 603461
RefSeq - XM_017020833
RefSeq - NM_001078645
RefSeq - NM_001318517
RefSeq - NM_001318518
RefSeq - NM_001330101
RefSeq - NM_003903
RefSeq - XM_005266206
RefSeq - XM_006719992
RefSeq - XM_006719993
RefSeq - XM_011534851
RefSeq - XM_011534853
RefSeq - XM_017020830
RefSeq - XM_017020831
RefSeq - XM_017020832
RefSeq Peptide - NP_001317034
RefSeq Peptide - NP_003894
RefSeq Peptide - NP_001072113
RefSeq Peptide - NP_001305446
RefSeq Peptide - NP_001305447
RefSeq Peptide - NP_001317030
RefSeq Peptide - NP_001317033
swissprot - Q13042
swissprot - A0A024RDZ2
swissprot - Q5T8C6
Ensembl - ENSG00000130177
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc16ENSDARG00000055470Danio rerio
 CDC16ENSGALG00000016816Gallus gallus
 Cdc16ENSMUSG00000038416Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome TAS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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