ENSG00000130528


Homo sapiens

Features
Gene ID: ENSG00000130528
  
Biological name :HRC
  
Synonyms : histidine rich calcium binding protein / HRC / P23327
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49151198
Gene end: 49155424
  
Corresponding Affymetrix probe sets: 207066_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469659
Ensembl peptide - ENSP00000470288
Ensembl peptide - ENSP00000252825
NCBI entrez gene - 3270     See in Manteia.
OMIM - 142705
RefSeq - NM_002152
RefSeq Peptide - NP_002143
swissprot - P23327
swissprot - M0QY84
swissprot - M0QZ43
Ensembl - ENSG00000130528
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-173d10.1ENSDARG00000045947Danio rerio
 HrcENSMUSG00000038239Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015666  Sarcoplasmic reticulum histidine-rich calcium-binding protein
 IPR019552  Histidine-rich calcium-binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0010460 positive regulation of heart rate IGI
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045823 positive regulation of heart contraction IGI
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IGI
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IGI
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IGI
 biological_processGO:1901899 positive regulation of relaxation of cardiac muscle IGI
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IGI
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0033018 sarcoplasmic reticulum lumen TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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