ENSMUSG00000038239


Mus musculus

Features
Gene ID: ENSMUSG00000038239
  
Biological name :Hrc
  
Synonyms : histidine rich calcium binding protein / Hrc
  
Possible biological names infered from orthology : P23327
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45335290
Gene end: 45338974
  
Corresponding Affymetrix probe sets: 10552919 (MoGene1.0st)   1419109_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082459
Ensembl peptide - ENSMUSP00000147299
NCBI entrez gene - 15464     See in Manteia.
MGI - MGI:96226
RefSeq - NM_010473
RefSeq Peptide - NP_034603
swissprot - G5E8J6
swissprot - A0A1B0GQY1
Ensembl - ENSMUSG00000038239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-173d10.1ENSDARG00000045947Danio rerio
 HRCENSG00000130528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015666  Sarcoplasmic reticulum histidine-rich calcium-binding protein
 IPR019552  Histidine-rich calcium-binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0008016 regulation of heart contraction IDA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IBA
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055074 calcium ion homeostasis IDA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IEA
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IEA
 biological_processGO:1901899 positive regulation of relaxation of cardiac muscle IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0009732 ventricular premature beat "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0020345 abnormal myocardial fiber currents "any anomaly in the electrical currents produced by cardiac ion channels, typically measured using whole-cell patch-clamp techniques" [http://www.ncbi.nlm.nih.gov/books/NBK7515/, PMID:21372286, PMID:25368181]
Show

Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

 MP:0020419 decreased cardiac muscle relaxation "inability or reduced ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [PMID:11565821, RGD:cur]
Show

Allelic Composition: Hrctm1.1Desa/Hrctm1.1Desa
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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