ENSG00000130988


Homo sapiens

Features
Gene ID: ENSG00000130988
  
Biological name :RGN
  
Synonyms : Q15493 / regucalcin / RGN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.3
Gene start: 47078355
Gene end: 47093314
  
Corresponding Affymetrix probe sets: 210751_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000253303
Ensembl peptide - ENSP00000338400
Ensembl peptide - ENSP00000380365
Ensembl peptide - ENSP00000406568
NCBI entrez gene - 9104     See in Manteia.
OMIM - 300212
RefSeq - XM_017029954
RefSeq - NM_001282848
RefSeq - NM_001282849
RefSeq - NM_004683
RefSeq - NM_152869
RefSeq - XM_006724567
RefSeq - XM_006724568
RefSeq Peptide - NP_690608
RefSeq Peptide - NP_001269777
RefSeq Peptide - NP_001269778
RefSeq Peptide - NP_004674
swissprot - Q15493
swissprot - V9HWF8
Ensembl - ENSG00000130988
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgnENSDARG00000098645Danio rerio
 RGNENSGALG00000016724Gallus gallus
 RgnENSMUSG00000023070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005511  Senescence marker protein-30 (SMP-30)
 IPR008367  Regucalcin
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013658  SMP-30/Gluconolactonase/LRE-like region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0010922 positive regulation of phosphatase activity IEA
 biological_processGO:0019853 L-ascorbic acid biosynthetic process IBA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032781 positive regulation of ATPase activity ISS
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling ISS
 biological_processGO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901318 negative regulation of flagellated sperm motility IEA
 biological_processGO:1901671 positive regulation of superoxide dismutase activity IEA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IEA
 biological_processGO:1902679 negative regulation of RNA biosynthetic process IEA
 biological_processGO:1903011 negative regulation of bone development IEA
 biological_processGO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1903611 negative regulation of calcium-dependent ATPase activity IEA
 biological_processGO:1903625 negative regulation of DNA catabolic process IEA
 biological_processGO:1903629 positive regulation of dUTP diphosphatase activity IEA
 biological_processGO:1903634 negative regulation of leucine-tRNA ligase activity IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004341 gluconolactonase activity IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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