ENSG00000131127


Homo sapiens

Features
Gene ID: ENSG00000131127
  
Biological name :ZNF141
  
Synonyms : Q15928 / zinc finger protein 141 / ZNF141
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 337814
Gene end: 384864
  
Corresponding Affymetrix probe sets: 206931_at (Human Genome U133 Plus 2.0 Array)   235580_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000240499
Ensembl peptide - ENSP00000425799
Ensembl peptide - ENSP00000424403
NCBI entrez gene - 7700     See in Manteia.
OMIM - 194648
RefSeq - NM_003441
RefSeq Peptide - NP_003432
swissprot - D6RIY0
swissprot - D6RB60
swissprot - Q15928
Ensembl - ENSG00000131127
  
Related genetic diseases (OMIM): 615226 - ?Polydactyly, postaxial, type A6, 615226

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT573016.1ENSMUSG00000114923Mus musculus
 Zfp457ENSMUSG00000055341Mus musculus
 Zfp595ENSMUSG00000057842Mus musculus
 Zfp65ENSMUSG00000071281Mus musculus
 Zfp759ENSMUSG00000057396Mus musculus
 Zfp953ENSMUSG00000098905Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B4DXR9 / ZNF732 / zinc finger protein 732ENSG0000018677778
ZNF595 / zinc finger protein 595ENSG0000027260267
Q9UII5 / ZNF107 / zinc finger protein 107ENSG0000019624766
ZNF43 / P17038 / zinc finger protein 43ENSG0000019852165
Q96N22 / ZNF681 / zinc finger protein 681ENSG0000019617265
A6NNF4 / ZNF726 / zinc finger protein 726ENSG0000021396764
ZNF718 / zinc finger protein 718ENSG0000025031264
Q86V71 / ZNF429 / zinc finger protein 429ENSG0000019701364
Q9Y2Q1 / ZNF257 / zinc finger protein 257ENSG0000019713464
Q6ZR52 / ZNF493 / zinc finger protein 493ENSG0000019626864
P0DKX0 / ZNF728 / zinc finger protein 728ENSG0000026906764
ZNF98 / A6NK75 / zinc finger protein 98ENSG0000019736063
ZNF66 / Q6ZN08 / zinc finger protein 66ENSG0000016022963
Q9H8G1 / ZNF430 / zinc finger protein 430ENSG0000011862062
Q8TD23 / ZNF675 / zinc finger protein 675ENSG0000019737262
O75373 / ZNF737 / zinc finger protein 737ENSG0000023744062
O75437 / ZNF254 / zinc finger protein 254ENSG0000021309662
ZNF92 / Q03936 / zinc finger protein 92ENSG0000014675762
ZNF723 / zinc finger protein 723ENSG0000026869660
P17019 / ZNF708 / zinc finger protein 708ENSG0000018214160


Protein motifs (from Interpro)
Interpro ID Name
 IPR001909  Krueppel-associated box
 IPR013087  Zinc finger C2H2-type
 IPR036051  KRAB domain superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0035108 limb morphogenesis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001162 Postaxial polydactyly (hands) "Supernumerary digits located at the ulnar side of the hand." [HPO:curators]
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 HP:0009374 Broad phalanges of the 5th finger "Increased width of the phalanges of the 5th finger." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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