ENSG00000133027


Homo sapiens

Features
Gene ID: ENSG00000133027
  
Biological name :PEMT
  
Synonyms : PEMT / phosphatidylethanolamine N-methyltransferase / Q9UBM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 17505563
Gene end: 17591708
  
Corresponding Affymetrix probe sets: 207621_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463112
Ensembl peptide - ENSP00000391288
Ensembl peptide - ENSP00000463713
Ensembl peptide - ENSP00000255389
Ensembl peptide - ENSP00000379127
Ensembl peptide - ENSP00000379128
Ensembl peptide - ENSP00000379129
NCBI entrez gene - 10400     See in Manteia.
OMIM - 602391
RefSeq - XM_017024016
RefSeq - NM_001267551
RefSeq - NM_001267552
RefSeq - NM_007169
RefSeq - NM_148172
RefSeq - NM_148173
RefSeq - XM_006721418
RefSeq Peptide - NP_009100
RefSeq Peptide - NP_680477
RefSeq Peptide - NP_680478
RefSeq Peptide - NP_001254480
RefSeq Peptide - NP_001254481
swissprot - Q9UBM1
swissprot - J3KTR2
swissprot - J3QLU8
swissprot - D3YTC7
Ensembl - ENSG00000133027
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pemtENSDARG00000103614Danio rerio
 PEMTENSGALG00000004875Gallus gallus
 PemtENSMUSG00000000301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007318  Phospholipid methyltransferase
 IPR024960  Phosphatidyl-N-methylethanolamine/Phosphatidylethanolamine N-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006650 glycerophospholipid metabolic process IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IBA
 biological_processGO:0006686 sphingomyelin biosynthetic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033273 response to vitamin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046498 S-adenosylhomocysteine metabolic process IEA
 biological_processGO:0046500 S-adenosylmethionine metabolic process IEA
 biological_processGO:0050747 positive regulation of lipoprotein metabolic process IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity IEA
 molecular_functionGO:0004608 phosphatidylethanolamine N-methyltransferase activity TAS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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