ENSMUSG00000000301


Mus musculus

Features
Gene ID: ENSMUSG00000000301
  
Biological name :Pemt
  
Synonyms : Pemt / Phosphatidylethanolamine N-methyltransferase / Q61907
  
Possible biological names infered from orthology : Q9UBM1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59970614
Gene end: 60046489
  
Corresponding Affymetrix probe sets: 10386460 (MoGene1.0st)   1450612_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000310
Ensembl peptide - ENSMUSP00000099754
Ensembl peptide - ENSMUSP00000116314
Ensembl peptide - ENSMUSP00000120364
Ensembl peptide - ENSMUSP00000099753
NCBI entrez gene - 18618     See in Manteia.
MGI - MGI:104535
RefSeq - XM_006532478
RefSeq - NM_001290011
RefSeq - NM_001290012
RefSeq - NM_001290013
RefSeq - NM_001290014
RefSeq - NM_008819
RefSeq Peptide - NP_001276943
RefSeq Peptide - NP_032845
RefSeq Peptide - NP_001276941
RefSeq Peptide - NP_001276940
RefSeq Peptide - NP_001276942
swissprot - Q61907
swissprot - B1ARD1
swissprot - B1ARC9
Ensembl - ENSMUSG00000000301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pemtENSDARG00000103614Danio rerio
 PEMTENSGALG00000004875Gallus gallus
 PEMTENSG00000133027Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007318  Phospholipid methyltransferase
 IPR024960  Phosphatidyl-N-methylethanolamine/Phosphatidylethanolamine N-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IEA
 biological_processGO:0006686 sphingomyelin biosynthetic process IMP
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005740 mitochondrial envelope TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity IEA
 molecular_functionGO:0004608 phosphatidylethanolamine N-methyltransferase activity ISS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: H2-Ab1em1Ygch/H2-Ab1em1Ygch
Genetic Background: NOD/ShiLtJ-H2-Ab1em1Ygch

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Ab1em1Ygch/H2-Ab1em1Ygch
Genetic Background: NOD/ShiLtJ-H2-Ab1em1Ygch

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Pemttm1J/Pemttm1J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0012338 decreased bile salt level "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith]
Show

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Pemttm1J/Pemttm1J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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