ENSG00000134248


Homo sapiens

Features
Gene ID: ENSG00000134248
  
Biological name :LAMTOR5
  
Synonyms : LAMTOR5 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 / O43504
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.3
Gene start: 110401249
Gene end: 110407942
  
Corresponding Affymetrix probe sets: 202299_s_at (Human Genome U133 Plus 2.0 Array)   202300_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435085
Ensembl peptide - ENSP00000480529
Ensembl peptide - ENSP00000473439
Ensembl peptide - ENSP00000473357
Ensembl peptide - ENSP00000256644
Ensembl peptide - ENSP00000434828
NCBI entrez gene - 10542     See in Manteia.
OMIM - 608521
RefSeq - NM_006402
RefSeq Peptide - NP_006393
swissprot - A0A0C4DGV4
swissprot - E9PLX3
swissprot - O43504
swissprot - R4GMU8
Ensembl - ENSG00000134248
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor5ENSDARG00000090194Danio rerio
 LAMTOR5ENSGALG00000000419Gallus gallus
 Q9D1L9ENSMUSG00000087260Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024135  Ragulator complex protein LAMTOR5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0019079 viral genome replication IEA
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0061462 protein localization to lysosome IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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