ENSMUSG00000087260


Mus musculus

Features
Gene ID: ENSMUSG00000087260
  
Biological name :Lamtor5
  
Synonyms : Lamtor5 / Q9D1L9 / Ragulator complex protein LAMTOR5
  
Possible biological names infered from orthology : late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 / O43504
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.3
Gene start: 107278858
Gene end: 107284082
  
Corresponding Affymetrix probe sets: 10495201 (MoGene1.0st)   10338780 (MoGene1.0st)   10342358 (MoGene1.0st)   10342875 (MoGene1.0st)   10343413 (MoGene1.0st)   10343469 (MoGene1.0st)   10344410 (MoGene1.0st)   1415759_a_at (Mouse Genome 430 2.0 Array)   1436152_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129012
Ensembl peptide - ENSMUSP00000143494
NCBI entrez gene - 68576     See in Manteia.
MGI - MGI:1915826
RefSeq - NM_026774
RefSeq Peptide - NP_081050
swissprot - G3UW70
swissprot - Q9D1L9
Ensembl - ENSMUSG00000087260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor5ENSDARG00000090194Danio rerio
 LAMTOR5ENSGALG00000000419Gallus gallus
 O43504ENSG00000134248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024135  Ragulator complex protein LAMTOR5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008361 regulation of cell size ISS
 biological_processGO:0019079 viral genome replication IEA
 biological_processGO:0032008 positive regulation of TOR signaling ISO
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0061462 protein localization to lysosome ISO
 biological_processGO:0071230 cellular response to amino acid stimulus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0032947 protein-containing complex scaffold activity ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Fgf3tm4b(EUCOMM)Hmgu/Fgf3tm4b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Fgf3tm4b(EUCOMM)Hmgu/Bay

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgf3tm4b(EUCOMM)Hmgu/Fgf3tm4b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Fgf3tm4b(EUCOMM)Hmgu/Bay

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
Show

Allelic Composition: Fgf3tm4b(EUCOMM)Hmgu/Fgf3tm4b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Fgf3tm4b(EUCOMM)Hmgu/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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