ENSG00000134452


Homo sapiens

Features
Gene ID: ENSG00000134452
  
Biological name :FBXO18
  
Synonyms : F-box protein, helicase, 18 / FBXO18 / Q8NFZ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 5890203
Gene end: 5937594
  
Corresponding Affymetrix probe sets: 1559561_at (Human Genome U133 Plus 2.0 Array)   224683_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355415
Ensembl peptide - ENSP00000369335
Ensembl peptide - ENSP00000380439
NCBI entrez gene - 84893     See in Manteia.
OMIM - 607222
RefSeq - XM_017016846
RefSeq - NM_001258452
RefSeq - NM_001258453
RefSeq - NM_032807
RefSeq - NM_178150
RefSeq - XM_011519748
RefSeq - XM_017016842
RefSeq - XM_017016843
RefSeq - XM_017016844
RefSeq - XM_017016845
RefSeq Peptide - NP_001245381
RefSeq Peptide - NP_001245382
RefSeq Peptide - NP_116196
RefSeq Peptide - NP_835363
swissprot - F6UZG9
swissprot - Q8NFZ0
Ensembl - ENSG00000134452
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo18ENSDARG00000062983Danio rerio
 F1ND48ENSGALG00000008162Gallus gallus
 Fbxo18ENSMUSG00000058594Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000212  DNA helicase, UvrD/REP type
 IPR001810  F-box domain
 IPR014017  UvrD-like DNA helicase, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008219 cell death IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0048478 replication fork protection IEA
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IEA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IMP
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015616 DNA translocase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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