ENSG00000134640


Homo sapiens

Features
Gene ID: ENSG00000134640
  
Biological name :MTNR1B
  
Synonyms : melatonin receptor 1B / MTNR1B / P49286
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q14.3
Gene start: 92969720
Gene end: 92985066
  
Corresponding Affymetrix probe sets: 208516_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257068
Ensembl peptide - ENSP00000436101
Ensembl peptide - ENSP00000433573
NCBI entrez gene - 4544     See in Manteia.
OMIM - 600804
RefSeq - NM_005959
RefSeq - XM_011542839
RefSeq Peptide - NP_005950
swissprot - E9PR36
swissprot - P49286
swissprot - H0YDG4
Ensembl - ENSG00000134640
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, type 2, susceptibility to}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P51049ENSDARG00000086493Danio rerio
 MTNR1BENSGALG00000017228Gallus gallus
 Mtnr1bENSMUSG00000050901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTNR1A / P48039 / melatonin receptor 1AENSG0000016841256
GPR50 / Q13585 / G protein-coupled receptor 50ENSG0000010219543
GPR135 / Q8IZ08 / G protein-coupled receptor 135ENSG0000018161919
AC018709.1ENSG0000027229712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000025  Melatonin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002278  Melatonin receptor 1A/1B
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027459  Melatonin receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007623 circadian rhythm IBA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008502 melatonin receptor activity TAS


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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