ENSG00000134900


Homo sapiens

Features
Gene ID: ENSG00000134900
  
Biological name :TPP2
  
Synonyms : P29144 / TPP2 / tripeptidyl peptidase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q33.1
Gene start: 102597003
Gene end: 102679958
  
Corresponding Affymetrix probe sets: 1569856_at (Human Genome U133 Plus 2.0 Array)   1569857_s_at (Human Genome U133 Plus 2.0 Array)   203374_s_at (Human Genome U133 Plus 2.0 Array)   203375_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365220
Ensembl peptide - ENSP00000365233
NCBI entrez gene - 7174     See in Manteia.
OMIM - 190470
RefSeq - XM_005254072
RefSeq - NM_001330588
RefSeq - NM_003291
RefSeq - XM_005254070
RefSeq - XM_005254071
RefSeq Peptide - NP_001317517
RefSeq Peptide - NP_003282
swissprot - Q5VZU9
swissprot - P29144
Ensembl - ENSG00000134900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpp2ENSDARG00000078751Danio rerio
 TPP2ENSGALG00000016865Gallus gallus
 Tpp2ENSMUSG00000041763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR015500  Peptidase S8, subtilisin-related
 IPR022229  Peptidase S8A, tripeptidyl peptidase II
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR034051  Tripeptidyl-peptidase II domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004177 aminopeptidase activity EXP
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008240 tripeptidyl-peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000403 Recurrent otitis media 
Show

 HP:0001269 Hemiparesis "Relatively mild weakness in the arm, leg, and in some cases the face on one side of the body." [HPO:curators]
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 HP:0001297 Stroke 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001888 Lymphopenia 
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 HP:0001890 Autoimmune hemolytic anemia 
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 HP:0001973 Immune thrombocytopenia 
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 HP:0002716 Lymphadenopathy 
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 HP:0002725 Systemic lupus erythematosus 
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 HP:0011343 Moderate global developmental delay "A moderate delay in the achievement of motor or mental milestones in the domains of development of a child." [DDD:hvfirth]
Show

 HP:0011947 Respiratory tract infection "An infection of the upper or lower respiratory tract." [HPO:probinson]
Show

 HP:0012115 Hepatitis "Inflammation of the liver." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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