Manteia - Molecule gene

ENSMUSG00000041763

Mus musculus

Features

Gene ID:	ENSMUSG00000041763

Biological name :	Tpp2

Synonyms :	Q64514 / Tpp2 / tripeptidyl peptidase II

Possible biological names infered from orthology :	P29144 / tripeptidyl peptidase 2

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C1.1
Gene start:	43933647
Gene end:	44003000

Corresponding Affymetrix probe sets:	10345930 (MoGene1.0st) 1421893_a_at (Mouse Genome 430 2.0 Array) 1421894_a_at (Mouse Genome 430 2.0 Array) 1430575_a_at (Mouse Genome 430 2.0 Array) 1430576_at (Mouse Genome 430 2.0 Array) 1438264_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000139918 Ensembl peptide - ENSMUSP00000140562 Ensembl peptide - ENSMUSP00000140474 Ensembl peptide - ENSMUSP00000140313 Ensembl peptide - ENSMUSP00000085244 Ensembl peptide - ENSMUSP00000139592 NCBI entrez gene - 22019 See in Manteia. MGI - MGI:102724 RefSeq - NM_009418 RefSeq - NM_001310540 RefSeq Peptide - NP_001297469 RefSeq Peptide - NP_033444 swissprot - Q64514 swissprot - A0A087WQR6 swissprot - A0A087WP19 swissprot - Q05DJ9 swissprot - A0A087WRC0 Ensembl - ENSMUSG00000041763

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tpp2	ENSDARG00000078751	Danio rerio
TPP2	ENSGALG00000016865	Gallus gallus
TPP2	ENSG00000134900	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000209	Peptidase S8/S53 domain
IPR015500	Peptidase S8, subtilisin-related
IPR022229	Peptidase S8A, tripeptidyl peptidase II
IPR022398	Peptidase S8, subtilisin, His-active site
IPR023828	Peptidase S8, subtilisin, Ser-active site
IPR034051	Tripeptidyl-peptidase II domain
IPR036852	Peptidase S8/S53 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0016604	nuclear body	ISO
molecular_function	GO:0004177	aminopeptidase activity	ISO
molecular_function	GO:0004252	serine-type endopeptidase activity	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0008240	tripeptidyl-peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0042277	peptide binding	IEA
molecular_function	GO:0042802	identical protein binding	ISO

Pathways (from Reactome)

Pathway description

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hprt^{tm2(CAG-Ppp1r3c)Jjg}/?,Nhlrc1^{tm1(KOMP)Vlcg}/Nhlrc1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hprt^{tm2(CAG-Ppp1r3c)Jjg}/?,Nhlrc1^{tm1(KOMP)Vlcg}/Nhlrc1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001511	disheveled coat	"coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001835	abnormal antigen presentation	"aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0001839	abnormal level of surface class I molecules	"deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003945	abnormal lymphocyte physiology	"abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005078	abnormal cytotoxic T cell physiology	"impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0006413	increased T cell apoptosis	"increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008049	increased memory T cell number	"greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0008076	abnormal CD4-positive T cell differentiation	"atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008080	abnormal CD8-positive T cell differentiation	"atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie Genetic Background: involves: 129S6/SvEvTac
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Lipg^tm1Tq/Lipg^tm1Tq Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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