ENSG00000136877


Homo sapiens

Features
Gene ID: ENSG00000136877
  
Biological name :FPGS
  
Synonyms : folylpolyglutamate synthase / FPGS / Q05932
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.11
Gene start: 127794597
Gene end: 127814327
  
Corresponding Affymetrix probe sets: 202945_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486766
Ensembl peptide - ENSP00000362322
Ensembl peptide - ENSP00000362325
Ensembl peptide - ENSP00000400007
Ensembl peptide - ENSP00000406328
Ensembl peptide - ENSP00000362344
Ensembl peptide - ENSP00000377309
NCBI entrez gene - 2356     See in Manteia.
OMIM - 136510
RefSeq - XM_017014566
RefSeq - NM_001018078
RefSeq - NM_001288803
RefSeq - NM_004957
RefSeq - XM_005251864
RefSeq - XM_011518439
RefSeq - XM_017014565
RefSeq Peptide - NP_001018088
RefSeq Peptide - NP_001275732
RefSeq Peptide - NP_004948
swissprot - Q5JU20
swissprot - Q05932
swissprot - Q5JU21
swissprot - Q5JU23
Ensembl - ENSG00000136877
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fpgsENSDARG00000044809Danio rerio
 FPGSENSGALG00000042460Gallus gallus
 FpgsENSMUSG00000009566Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001645  Folylpolyglutamate synthetase
 IPR013221  Mur ligase, central
 IPR018109  Folylpolyglutamate synthetase, conserved site
 IPR023600  Folylpolyglutamate synthase, eukaryota
 IPR036565  Mur-like, catalytic domain superfamily
 IPR036615  Mur ligase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006536 glutamate metabolic process IDA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0006760 folic acid-containing compound metabolic process IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009396 folic acid-containing compound biosynthetic process IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0046901 tetrahydrofolylpolyglutamate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004326 tetrahydrofolylpolyglutamate synthase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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