ENSMUSG00000009566


Mus musculus

Features
Gene ID: ENSMUSG00000009566
  
Biological name :Fpgs
  
Synonyms : Folylpolyglutamate synthase, mitochondrial / Fpgs / P48760
  
Possible biological names infered from orthology : folylpolyglutamate synthase / Q05932
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32682609
Gene end: 32704145
  
Corresponding Affymetrix probe sets: 10481654 (MoGene1.0st)   1460673_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116434
Ensembl peptide - ENSMUSP00000141899
Ensembl peptide - ENSMUSP00000141705
Ensembl peptide - ENSMUSP00000028148
NCBI entrez gene - 14287     See in Manteia.
MGI - MGI:95576
RefSeq - XM_006497696
RefSeq - XM_006497697
RefSeq - XM_006497698
RefSeq - XM_011239021
RefSeq - NM_010236
RefSeq Peptide - NP_034366
swissprot - P48760
swissprot - A0A0A6YX96
swissprot - A0A0A6YWU6
swissprot - A2AK70
Ensembl - ENSMUSG00000009566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fpgsENSDARG00000044809Danio rerio
 FPGSENSGALG00000042460Gallus gallus
 FPGSENSG00000136877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001645  Folylpolyglutamate synthetase
 IPR018109  Folylpolyglutamate synthetase, conserved site
 IPR023600  Folylpolyglutamate synthase, eukaryota
 IPR036565  Mur-like, catalytic domain superfamily
 IPR036615  Mur ligase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006536 glutamate metabolic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0006760 folic acid-containing compound metabolic process IEA
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009396 folic acid-containing compound biosynthetic process IEA
 biological_processGO:0046901 tetrahydrofolylpolyglutamate biosynthetic process ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004326 tetrahydrofolylpolyglutamate synthase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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