ENSG00000136942


Homo sapiens

Features
Gene ID: ENSG00000136942
  
Biological name :RPL35
  
Synonyms : P42766 / ribosomal protein L35 / RPL35
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 124857880
Gene end: 124861981
  
Corresponding Affymetrix probe sets: 200002_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486088
Ensembl peptide - ENSP00000259469
Ensembl peptide - ENSP00000362671
Ensembl peptide - ENSP00000437215
NCBI entrez gene - 11224     See in Manteia.
RefSeq - NM_007209
RefSeq Peptide - NP_009140
swissprot - F2Z388
swissprot - P42766
Ensembl - ENSG00000136942
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl35ENSDARG00000018334Danio rerio
 RPL35ENSGALG00000035677Gallus gallus
 Gm10269ENSMUSG00000091449Mus musculus
 Gm2000ENSMUSG00000078193Mus musculus
 Rpl35ENSMUSG00000062997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001854  Ribosomal protein L29/L35
 IPR018254  Ribosomal protein L29, conserved site
 IPR036049  Ribosomal protein L29/L35 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0019083 viral transcription TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005730 nucleolus TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003729 mRNA binding TAS
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000078 Abnormality of the genital tract 
Show

 HP:0000079 Abnormality of the urinary tract 
Show

 HP:0000175 Cleft palate "Cleft palate is a developmental defect of the `palate` (FMA:54549) resulting from a failure of fusion of the palatine processes." [HPO:curators]
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 HP:0000179 Prominent lower lip "Increased thickness of the lower lip, leading to a prominent appearance of the lower lip." [HPO:curators]
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 HP:0000457 Flat nose 
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 HP:0000823 Delayed puberty 
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 HP:0000980 Pallor 
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 HP:0001155 Abnormality of the hand "An abnormality affecting one or both hands." [HPO:curators]
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 HP:0001972 Macrocytic anemia 
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 HP:0002076 Migraine 
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 HP:0002488 Acute leukemia 
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 HP:0003196 Nasal hypoplasia "Underdevelopment of the `nose` (FMA:46472)." [HPO:probinson]
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0011675 Arrhythmia "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." [DDD:dbrown, pmid:19063792]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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