ENSG00000137055


Homo sapiens

Features
Gene ID: ENSG00000137055
  
Biological name :PLAA
  
Synonyms : phospholipase A2 activating protein / PLAA / Q9Y263
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p21.2
Gene start: 26904083
Gene end: 26947463
  
Corresponding Affymetrix probe sets: 209532_at (Human Genome U133 Plus 2.0 Array)   209533_s_at (Human Genome U133 Plus 2.0 Array)   235394_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380460
Ensembl peptide - ENSP00000429372
Ensembl peptide - ENSP00000430447
Ensembl peptide - ENSP00000430734
Ensembl peptide - ENSP00000428111
NCBI entrez gene - 9373     See in Manteia.
OMIM - 603873
RefSeq - XM_017015319
RefSeq - NM_001031689
RefSeq - NM_001321546
RefSeq - XM_011518072
RefSeq Peptide - NP_001308475
RefSeq Peptide - NP_001026859
swissprot - H0YC16
swissprot - Q9Y263
swissprot - H0YAU9
swissprot - H0YBW4
swissprot - E5RIM3
Ensembl - ENSG00000137055
  
Related genetic diseases (OMIM): 617527 - Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies, 617527
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plaaENSDARG00000042728Danio rerio
 PLAAENSGALG00000001782Gallus gallus
 PlaaENSMUSG00000028577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011989  Armadillo-like helical
 IPR013535  PUL domain
 IPR015155  PLAA family ubiquitin binding domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR020472  G-protein beta WD-40 repeat
 IPR033510  PLAA/Doa1/Lub1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010992 ubiquitin recycling IBA
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0032430 positive regulation of phospholipase A2 activity IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:1900045 negative regulation of protein K63-linked ubiquitination IEA
 biological_processGO:1903423 positive regulation of synaptic vesicle recycling IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:2001224 positive regulation of neuron migration IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016005 phospholipase A2 activator activity TAS
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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