ENSMUSG00000028577


Mus musculus

Features
Gene ID: ENSMUSG00000028577
  
Biological name :Plaa
  
Synonyms : P27612 / Phospholipase A-2-activating protein / Plaa
  
Possible biological names infered from orthology : Q9Y263
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C5
Gene start: 94567514
Gene end: 94603244
  
Corresponding Affymetrix probe sets: 10514405 (MoGene1.0st)   1426019_at (Mouse Genome 430 2.0 Array)   1429707_at (Mouse Genome 430 2.0 Array)   1435001_at (Mouse Genome 430 2.0 Array)   1444647_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102724
Ensembl peptide - ENSMUSP00000116530
NCBI entrez gene - 18786     See in Manteia.
MGI - MGI:104810
RefSeq - NM_172695
RefSeq Peptide - NP_766283
swissprot - F7D1R5
swissprot - P27612
Ensembl - ENSMUSG00000028577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plaaENSDARG00000042728Danio rerio
 PLAAENSGALG00000001782Gallus gallus
 PLAAENSG00000137055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR013535  PUL domain
 IPR015155  PLAA family ubiquitin binding domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR033510  PLAA/Doa1/Lub1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006693 prostaglandin metabolic process IMP
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010992 ubiquitin recycling IBA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0032430 positive regulation of phospholipase A2 activity IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:1900045 negative regulation of protein K63-linked ubiquitination IMP
 biological_processGO:1903423 positive regulation of synaptic vesicle recycling IMP
 biological_processGO:1903861 positive regulation of dendrite extension IMP
 biological_processGO:2001224 positive regulation of neuron migration IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016005 phospholipase A2 activator activity IDA
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0010008 abnormal Purkinje cell migration "defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rbm24tm1.1Xch/Rbm24tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Plaaem1Pmi/Plaatm1(NCOM)Cmhd
Genetic Background: either (involves: C57BL/6J * C57BL/6NCrl) or (involves: C57BL/6J * C57BL/6NCrl * CD1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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