ENSG00000138071


Homo sapiens

Features
Gene ID: ENSG00000138071
  
Biological name :ACTR2
  
Synonyms : ACTR2 / ARP2 actin related protein 2 homolog / P61160
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p14
Gene start: 65227753
Gene end: 65271253
  
Corresponding Affymetrix probe sets: 1554390_s_at (Human Genome U133 Plus 2.0 Array)   1558015_s_at (Human Genome U133 Plus 2.0 Array)   200727_s_at (Human Genome U133 Plus 2.0 Array)   200728_at (Human Genome U133 Plus 2.0 Array)   200729_s_at (Human Genome U133 Plus 2.0 Array)   234210_x_at (Human Genome U133 Plus 2.0 Array)   234212_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367220
Ensembl peptide - ENSP00000490923
Ensembl peptide - ENSP00000490877
Ensembl peptide - ENSP00000437383
Ensembl peptide - ENSP00000260641
NCBI entrez gene - 10097     See in Manteia.
OMIM - 604221
RefSeq - NM_005722
RefSeq - NM_001005386
RefSeq Peptide - NP_001005386
RefSeq Peptide - NP_005713
swissprot - P61160
swissprot - A0A1B0GWD0
swissprot - F5H6T1
swissprot - A0A1B0GWH0
Ensembl - ENSG00000138071
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actr2aENSDARG00000052438Danio rerio
 actr2bENSDARG00000070076Danio rerio
 zgc:101810ENSDARG00000004658Danio rerio
 ACTR2ENSGALG00000008779Gallus gallus
 Actr2ENSMUSG00000020152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACTL8 / Q9H568 / actin like 8ENSG0000011714827
ACTL10 / Q5JWF8 / actin like 10ENSG0000018258418


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR020902  Actin/actin-like conserved site
 IPR027306  Actin-related protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008356 asymmetric cell division IEA
 biological_processGO:0016344 meiotic chromosome movement towards spindle pole IEA
 biological_processGO:0016482 cytosolic transport IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0033206 meiotic cytokinesis IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0035984 cellular response to trichostatin A IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051653 spindle localization IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030478 actin cap IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0061825 podosome core IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071437 invadopodium IEA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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