ENSMUSG00000020152


Mus musculus

Features
Gene ID: ENSMUSG00000020152
  
Biological name :Actr2
  
Synonyms : Actin-related protein 2 / Actr2 / P61161
  
Possible biological names infered from orthology : ARP2 actin related protein 2 homolog / P61160
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.1
Gene start: 20062304
Gene end: 20112913
  
Corresponding Affymetrix probe sets: 10384522 (MoGene1.0st)   1441660_at (Mouse Genome 430 2.0 Array)   1452587_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000137
NCBI entrez gene - 66713     See in Manteia.
MGI - MGI:1913963
RefSeq - XM_006514780
RefSeq - NM_146243
RefSeq Peptide - NP_666355
swissprot - P61161
swissprot - Q5SW83
Ensembl - ENSMUSG00000020152
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actr2aENSDARG00000052438Danio rerio
 actr2bENSDARG00000070076Danio rerio
 zgc:101810ENSDARG00000004658Danio rerio
 ACTR2ENSGALG00000008779Gallus gallus
 ACTR2ENSG00000138071Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2AKE7 / Actl10 / actin-like 10 / Q5JWF8*ENSMUSG0000007812924


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR020902  Actin/actin-like conserved site
 IPR027306  Actin-related protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IGI
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008356 asymmetric cell division IGI
 biological_processGO:0016344 meiotic chromosome movement towards spindle pole IGI
 biological_processGO:0016482 cytosolic transport IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0033206 meiotic cytokinesis IGI
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation ISO
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0035984 cellular response to trichostatin A IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051321 meiotic cell cycle IGI
 biological_processGO:0051653 spindle localization IGI
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071346 cellular response to interferon-gamma IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex ISO
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030478 actin cap IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0061825 podosome core IEA
 cellular_componentGO:0071437 invadopodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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