ENSG00000138356


Homo sapiens

Features
Gene ID: ENSG00000138356
  
Biological name :AOX1
  
Synonyms : aldehyde oxidase 1 / AOX1 / Q06278
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.1
Gene start: 200585868
Gene end: 200677064
  
Corresponding Affymetrix probe sets: 205082_s_at (Human Genome U133 Plus 2.0 Array)   205083_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413326
Ensembl peptide - ENSP00000260930
Ensembl peptide - ENSP00000363832
Ensembl peptide - ENSP00000392485
NCBI entrez gene - 316     See in Manteia.
OMIM - 602841
RefSeq - XM_017003947
RefSeq - NM_001159
RefSeq - XM_011511062
RefSeq - XM_017003946
RefSeq Peptide - NP_001150
swissprot - Q06278
swissprot - H7BXF7
swissprot - H7C3Q1
swissprot - C9J244
Ensembl - ENSG00000138356
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aox6ENSDARG00000020054Danio rerio
 Aox1ENSMUSG00000063558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
XDH / P47989 / xanthine dehydrogenaseENSG0000015812550


Protein motifs (from Interpro)
Interpro ID Name
 IPR000674  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR002346  Molybdopterin dehydrogenase, FAD-binding
 IPR002888  [2Fe-2S]-binding
 IPR005107  CO dehydrogenase flavoprotein, C-terminal
 IPR006058  2Fe-2S ferredoxin, iron-sulphur binding site
 IPR008274  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
 IPR012675  Beta-grasp domain superfamily
 IPR014313  Aldehyde oxidase
 IPR016166  FAD-binding, type 2
 IPR016167  FAD-binding, type 2, subdomain 1
 IPR016208  Aldehyde oxidase/xanthine dehydrogenase
 IPR022407  Oxidoreductase, molybdopterin binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily
 IPR036318  FAD-binding, type 2-like superfamily
 IPR036683  CO dehydrogenase flavoprotein, C-terminal domain superfamily
 IPR036856  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
 IPR036884  [2Fe-2S]-binding domain superfamily
 IPR037165  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009115 xanthine catabolic process IBA
 biological_processGO:0017144 drug metabolic process IDA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042816 vitamin B6 metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004031 aldehyde oxidase activity TAS
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043546 molybdopterin cofactor binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IBA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA
 molecular_functionGO:0102797 geranial:oxygen oxidoreductase activity IEA
 molecular_functionGO:0102798 heptaldehyde:oxygen oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Vitamins B6 activation to pyridoxal phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138356 AOX1 / Q06278 / aldehyde oxidase 1  / complex






 

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