ENSG00000142675


Homo sapiens

Features
Gene ID: ENSG00000142675
  
Biological name :CNKSR1
  
Synonyms : CNKSR1 / connector enhancer of kinase suppressor of Ras 1 / Q969H4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 26177403
Gene end: 26189886
  
Corresponding Affymetrix probe sets: 204740_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432057
Ensembl peptide - ENSP00000431817
Ensembl peptide - ENSP00000434047
Ensembl peptide - ENSP00000437038
Ensembl peptide - ENSP00000435880
Ensembl peptide - ENSP00000354609
Ensembl peptide - ENSP00000363371
NCBI entrez gene - 10256     See in Manteia.
OMIM - 603272
RefSeq - XM_011540485
RefSeq - NM_001297647
RefSeq - NM_001297648
RefSeq - NM_006314
RefSeq - XM_011540484
RefSeq Peptide - NP_001284577
RefSeq Peptide - NP_006305
RefSeq Peptide - NP_001284576
swissprot - E9PS82
swissprot - E9PIE0
swissprot - G3V160
swissprot - Q53GM7
swissprot - H0YDP5
swissprot - Q969H4
swissprot - B4DXN4
Ensembl - ENSG00000142675
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnksr1ENSDARG00000032932Danio rerio
 CNKSR1ENSGALG00000046299Gallus gallus
 Cnksr1ENSMUSG00000028841Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNKSR2 / Q8WXI2 / connector enhancer of kinase suppressor of Ras 2ENSG0000014997032
CNKSR3 / Q6P9H4 / CNKSR family member 3ENSG0000015372120
IPCEF1 / Q8WWN9 / interaction protein for cytohesin exchange factors 1ENSG0000007470615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017874  CRIC domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007265 Ras protein signal transduction IPI
 biological_processGO:0007266 Rho protein signal transduction IPI
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction TAS
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030674 protein binding, bridging IDA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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