ENSG00000143498


Homo sapiens

Features
Gene ID: ENSG00000143498
  
Biological name :TAF1A
  
Synonyms : Q15573 / TAF1A / TATA-box binding protein associated factor, RNA polymerase I subunit A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 222557902
Gene end: 222589933
  
Corresponding Affymetrix probe sets: 206613_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000327072
Ensembl peptide - ENSP00000339976
Ensembl peptide - ENSP00000355856
Ensembl peptide - ENSP00000375755
NCBI entrez gene - 9015     See in Manteia.
OMIM - 604903
RefSeq - XM_017002760
RefSeq - NM_001201536
RefSeq - NM_005681
RefSeq - NM_139352
RefSeq - XM_006711612
RefSeq - XM_006711613
RefSeq - XM_017002758
RefSeq - XM_017002759
RefSeq Peptide - NP_001188465
RefSeq Peptide - NP_005672
RefSeq Peptide - NP_647603
swissprot - Q15573
swissprot - Q5JRA7
Ensembl - ENSG00000143498
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf1aENSDARG00000052471Danio rerio
 TAF1AENSGALG00000009441Gallus gallus
 Taf1aENSMUSG00000072258Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR016629  RNA polymerase I, subunit A (TATA-binding protein-associated factor)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I TAS
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 cellular_componentGO:0000120 RNA polymerase I transcription factor complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
Show

 HP:0000982 Palmoplantar keratoderma 
Show

 HP:0001644 Dilated cardiomyopathy 
Show

 HP:0001874 Abnormality of neutrophil 
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 HP:0003198 Myopathy 
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 HP:0003236 Elevated serum creatine phosphokinase 
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 HP:0003457 Abnormal EMG findings "Abnormal results of investigations using electromyography (EMG)." [HPO:curators]
Show

 HP:0100578 Lipoatrophy "Localized loss of fat tissue." [HPO:sdoelken]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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