ENSG00000143520


Homo sapiens

Features
Gene ID: ENSG00000143520
  
Biological name :FLG2
  
Synonyms : filaggrin family member 2 / FLG2 / Q5D862
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 152348735
Gene end: 152360006
  
Corresponding Affymetrix probe sets: 1569410_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373370
NCBI entrez gene - 388698     See in Manteia.
OMIM - 616284
RefSeq - NM_001014342
RefSeq - XM_011509531
RefSeq Peptide - NP_001014364
swissprot - Q5D862
Ensembl - ENSG00000143520
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRNNENSGALG00000027316Gallus gallus
 Flg2ENSMUSG00000049133Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HRNR / Q86YZ3 / hornerinENSG0000019791538
FLG / P20930 / filaggrinENSG0000014363127
RPTN / Q6XPR3 / repetinENSG0000021585310
TCHH / Q07283 / trichohyalinENSG000001594508
Q5QJ38 / TCHHL1 / trichohyalin like 1ENSG000001828986
CRNN / Q9UBG3 / cornulinENSG000001435366


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR003303  Filaggrin
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR034325  S-100


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0061436 establishment of skin barrier IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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