ENSG00000144035


Homo sapiens

Features
Gene ID: ENSG00000144035
  
Biological name :NAT8
  
Synonyms : N-acetyltransferase 8 (putative) / NAT8 / Q9UHE5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.1
Gene start: 73640832
Gene end: 73642393
  
Corresponding Affymetrix probe sets: 206963_s_at (Human Genome U133 Plus 2.0 Array)   210289_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000272425
NCBI entrez gene - 9027     See in Manteia.
OMIM - 606716
RefSeq - NM_003960
RefSeq Peptide - NP_003951
swissprot - Q9UHE5
Ensembl - ENSG00000144035
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR559945.2ENSDARG00000106491Danio rerio
 si:ch211-195e19.1ENSDARG00000078991Danio rerio
 Nat8ENSMUSG00000030004Mus musculus
 Nat8f1ENSMUSG00000057103Mus musculus
 Nat8f2ENSMUSG00000033634Mus musculus
 Nat8f3ENSMUSG00000051262Mus musculus
 Nat8f4ENSMUSG00000068299Mus musculus
 Nat8f5ENSMUSG00000079494Mus musculus
 Nat8f6ENSMUSG00000079495Mus musculus
 Nat8f7ENSMUSG00000089694Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NAT8L / Q8N9F0 / N-acetyltransferase 8 likeENSG0000018581830
NAT8B / N-acetyltransferase 8B (putative, gene/pseudogene)ENSG0000020487212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR016181  Acyl-CoA N-acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0018003 peptidyl-lysine N6-acetylation IDA
 biological_processGO:0042493 response to drug TAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0050435 amyloid-beta metabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0047198 cysteine-S-conjugate N-acetyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186318 BACE1 / P56817 / beta-secretase 1  / reaction






 

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