ENSMUSG00000079494


Mus musculus

Features
Gene ID: ENSMUSG00000079494
  
Biological name :Nat8f5
  
Synonyms : N-acetyltransferase 8 (GCN5-related) family member 5 / Nat8f5 / Q9QXS8
  
Possible biological names infered from orthology : N-acetyltransferase 8 (putative) / NAT8 / Q9UHE5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 85817218
Gene end: 85820972
  
Corresponding Affymetrix probe sets: 10545874 (MoGene1.0st)   1424811_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032074
NCBI entrez gene - 69049     See in Manteia.
MGI - MGI:1916299
RefSeq - NM_023493
RefSeq Peptide - NP_075982
swissprot - Q9QXS8
Ensembl - ENSMUSG00000079494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR559945.2ENSDARG00000106491Danio rerio
 si:ch211-195e19.1ENSDARG00000078991Danio rerio
 NAT8ENSG00000144035Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nat8 / Q9JIY7 / N-acetyltransferase 8 / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000003000470
Nat8f4 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000006829967
Nat8f1 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000005710367
Nat8f2 / Q8CHQ9 / N-acetyltransferase 8 (GCN5-related) family member 2 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000003363464
Nat8f6 / Q9JIY8 / N-acetyltransferase 8 (GCN5-related) family member 6 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000007949554
Nat8f7 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000008969454
Nat8f3 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000005126254
Nat8l / N-acetyltransferase 8 like / Q8N9F0*ENSMUSG0000004814231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR016181  Acyl-CoA N-acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second NAS
 biological_processGO:0007162 negative regulation of cell adhesion ISA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISA
 cellular_componentGO:0005794 Golgi apparatus ISA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0008080 N-acetyltransferase activity NAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0010476 coronary fistula "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0011666 double outlet right ventricle, ventricular defect committed to aorta "a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]
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Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
Show

Allelic Composition: Tjp1tm1Sats/Tjp1+
Genetic Background: B6.Cg-Tjp1tm1Sats

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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