ENSMUSG00000048142


Mus musculus

Features
Gene ID: ENSMUSG00000048142
  
Biological name :Nat8l
  
Synonyms : N-acetyltransferase 8 like / Nat8l
  
Possible biological names infered from orthology : Q8N9F0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 33995984
Gene end: 34005916
  
Corresponding Affymetrix probe sets: 10521168 (MoGene1.0st)   1435842_at (Mouse Genome 430 2.0 Array)   1436702_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059313
NCBI entrez gene - 269642     See in Manteia.
MGI - MGI:2447776
RefSeq - NM_001001985
RefSeq Peptide - NP_001001985
swissprot - A0A0R4J0R4
Ensembl - ENSMUSG00000048142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nat8lENSDARG00000077256Danio rerio
 ENSGALG00000032113Gallus gallus
 ENSGALG00000029321Gallus gallus
 NAT8LENSG00000185818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nat8 / Q9JIY7 / N-acetyltransferase 8 / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000003000426
Nat8f1 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000005710325
Nat8f5 / Q9QXS8 / N-acetyltransferase 8 (GCN5-related) family member 5 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000007949423
Nat8f6 / Q9JIY8 / N-acetyltransferase 8 (GCN5-related) family member 6 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000007949523
Nat8f3 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000005126223
Nat8f2 / Q8CHQ9 / N-acetyltransferase 8 (GCN5-related) family member 2 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000003363423
Nat8f7 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000008969423
Nat8f4 / NAT8* / Q9UHE5* / N-acetyltransferase 8 (putative)*ENSMUSG0000006829923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR016181  Acyl-CoA N-acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0017188 aspartate N-acetyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8ltm1.2Meck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8ltm1.2Meck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8ltm1.2Meck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspanur7/Aspanur7,Nat8ltm1.2Meck/Nat8l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011621 abnormal habituation to a novel object "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel object" [MGI:csmith]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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