ENSG00000145241


Homo sapiens

Features
Gene ID: ENSG00000145241
  
Biological name :CENPC
  
Synonyms : CENPC / centromere protein C / Q03188
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.2
Gene start: 67468748
Gene end: 67545606
  
Corresponding Affymetrix probe sets: 204739_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273853
Ensembl peptide - ENSP00000421234
Ensembl peptide - ENSP00000425255
Ensembl peptide - ENSP00000426078
NCBI entrez gene - 1060     See in Manteia.
OMIM - 117141
RefSeq - XM_011531542
RefSeq - NM_001812
RefSeq - XM_006714064
RefSeq Peptide - NP_001803
swissprot - Q03188
swissprot - H0Y9W1
swissprot - H0Y8J2
Ensembl - ENSG00000145241
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CENPCENSGALG00000011683Gallus gallus
 Cenpc1ENSMUSG00000029253Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011051  RmlC-like cupin domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR025974  Mif2/CENP-C cupin domain
 IPR028052  Kinetochore assembly subunit CENP-C, N-terminal domain
 IPR028386  Centromere protein C/Mif2/cnp3
 IPR028931  CENP-C, middle DNMT3B-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IBA
 biological_processGO:0051382 kinetochore assembly IEA
 biological_processGO:0051455 attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IBA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IEA
 cellular_componentGO:0032154 cleavage furrow IDA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0090543 Flemming body IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0019237 centromeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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