ENSMUSG00000029253


Mus musculus

Features
Gene ID: ENSMUSG00000029253
  
Biological name :Cenpc1
  
Synonyms : Cenpc1 / Centromere protein C / P49452
  
Possible biological names infered from orthology : CENPC / Q03188
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E1
Gene start: 86012024
Gene end: 86065583
  
Corresponding Affymetrix probe sets: 10530892 (MoGene1.0st)   1420441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031170
NCBI entrez gene - 12617     See in Manteia.
MGI - MGI:99700
RefSeq - XM_017320638
RefSeq - NM_007683
RefSeq - XM_017320636
RefSeq - XM_017320637
RefSeq - XM_006534738
RefSeq - XM_006534739
RefSeq - XM_017320635
RefSeq Peptide - NP_031709
swissprot - P49452
Ensembl - ENSMUSG00000029253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CENPCENSGALG00000011683Gallus gallus
 CENPCENSG00000145241Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011051  RmlC-like cupin domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR025974  Mif2/CENP-C cupin domain
 IPR028052  Kinetochore assembly subunit CENP-C, N-terminal domain
 IPR028386  Centromere protein C/Mif2/cnp3
 IPR028931  CENP-C, middle DNMT3B-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IBA
 biological_processGO:0051382 kinetochore assembly IBA
 biological_processGO:0051455 attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IBA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019237 centromeric DNA binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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