ENSG00000145730


Homo sapiens

Features
Gene ID: ENSG00000145730
  
Biological name :PAM
  
Synonyms : P19021 / PAM / peptidylglycine alpha-amidating monooxygenase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q21.1
Gene start: 102753981
Gene end: 103031105
  
Corresponding Affymetrix probe sets: 202336_s_at (Human Genome U133 Plus 2.0 Array)   212958_x_at (Human Genome U133 Plus 2.0 Array)   214620_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420851
Ensembl peptide - ENSP00000403461
Ensembl peptide - ENSP00000421569
Ensembl peptide - ENSP00000426448
Ensembl peptide - ENSP00000424203
Ensembl peptide - ENSP00000423763
Ensembl peptide - ENSP00000423611
Ensembl peptide - ENSP00000421823
Ensembl peptide - ENSP00000282992
Ensembl peptide - ENSP00000302544
Ensembl peptide - ENSP00000306100
Ensembl peptide - ENSP00000314638
Ensembl peptide - ENSP00000369125
Ensembl peptide - ENSP00000396493
NCBI entrez gene - 5066     See in Manteia.
OMIM - 170270
RefSeq - XM_017009516
RefSeq - XM_017009500
RefSeq - XM_017009501
RefSeq - XM_017009502
RefSeq - XM_017009503
RefSeq - XM_017009504
RefSeq - XM_017009505
RefSeq - XM_017009506
RefSeq - XM_017009507
RefSeq - XM_017009508
RefSeq - XM_017009509
RefSeq - XM_017009510
RefSeq - XM_017009511
RefSeq - XM_017009512
RefSeq - XM_017009513
RefSeq - XM_017009514
RefSeq - XM_017009515
RefSeq - NM_000919
RefSeq - NM_001177306
RefSeq - NM_001319943
RefSeq - NM_138766
RefSeq - NM_138821
RefSeq - NM_138822
RefSeq - XM_011543419
RefSeq - XM_017009495
RefSeq - XM_017009496
RefSeq - XM_017009497
RefSeq - XM_017009498
RefSeq - XM_017009499
RefSeq Peptide - NP_001170777
RefSeq Peptide - NP_001306872
RefSeq Peptide - NP_620121
RefSeq Peptide - NP_620176
RefSeq Peptide - NP_620177
RefSeq Peptide - NP_000910
swissprot - H0Y9I4
swissprot - H7BYD9
swissprot - D6RG20
swissprot - P19021
swissprot - D6R961
swissprot - D6RF09
swissprot - D6RDU2
swissprot - D6RCD5
swissprot - D6RAQ2
swissprot - F8W8D9
Ensembl - ENSG00000145730
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pamENSDARG00000100170Danio rerio
 PAMENSGALG00000015256Gallus gallus
 PamENSMUSG00000026335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DBH / P09172 / dopamine beta-hydroxylaseENSG0000012345411
MOXD1 / Q6UVY6 / monooxygenase DBH like 1ENSG0000007993110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000323  Copper type II, ascorbate-dependent monooxygenase, N-terminal
 IPR000720  Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
 IPR001258  NHL repeat
 IPR008977  PHM/PNGase F domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013017  NHL repeat, subgroup
 IPR014783  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
 IPR014784  Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
 IPR020611  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
 IPR024548  Copper type II ascorbate-dependent monooxygenase, C-terminal
 IPR036939  Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001519 peptide amidation IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006518 peptide metabolic process IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0009404 toxin metabolic process IEA
 biological_processGO:0018032 protein amidation IEA
 biological_processGO:0019538 protein metabolic process IEA
 biological_processGO:0022602 ovulation cycle process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0050708 regulation of protein secretion IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060173 limb development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004504 peptidylglycine monooxygenase activity IEA
 molecular_functionGO:0004598 peptidylamidoglycolate lyase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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