ENSG00000147649


Homo sapiens

Features
Gene ID: ENSG00000147649
  
Biological name :MTDH
  
Synonyms : metadherin / MTDH / Q86UE4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q22.1
Gene start: 97644179
Gene end: 97728770
  
Corresponding Affymetrix probe sets: 1559822_s_at (Human Genome U133 Plus 2.0 Array)   212248_at (Human Genome U133 Plus 2.0 Array)   212250_at (Human Genome U133 Plus 2.0 Array)   212251_at (Human Genome U133 Plus 2.0 Array)   227277_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429642
Ensembl peptide - ENSP00000428168
Ensembl peptide - ENSP00000428703
Ensembl peptide - ENSP00000429289
Ensembl peptide - ENSP00000338235
NCBI entrez gene - 92140     See in Manteia.
OMIM - 610323
RefSeq - XM_017013968
RefSeq - XM_005251099
RefSeq - XM_011517367
RefSeq - XM_011517368
RefSeq - XM_011517369
RefSeq - XM_011517370
RefSeq - XM_017013966
RefSeq - XM_017013967
RefSeq - NM_178812
RefSeq Peptide - NP_848927
swissprot - H0YB56
swissprot - H0YBE0
swissprot - E5RJU9
swissprot - A0A024R9D2
swissprot - Q86UE4
swissprot - H0YBJ8
Ensembl - ENSG00000147649
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtdhaENSDARG00000014159Danio rerio
 mtdhbENSDARG00000004939Danio rerio
 MTDHENSGALG00000034050Gallus gallus
 MtdhENSMUSG00000022255Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031402  Protein LYRIC


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0046581 intercellular canaliculus ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003713 transcription coactivator activity IMP
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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