ENSMUSG00000022255


Mus musculus

Features
Gene ID: ENSMUSG00000022255
  
Biological name :Mtdh
  
Synonyms : Mtdh / Protein LYRIC / Q80WJ7
  
Possible biological names infered from orthology : metadherin / Q86UE4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 34082694
Gene end: 34145624
  
Corresponding Affymetrix probe sets: 10423577 (MoGene1.0st)   1421110_at (Mouse Genome 430 2.0 Array)   1434882_at (Mouse Genome 430 2.0 Array)   1434883_at (Mouse Genome 430 2.0 Array)   1434884_at (Mouse Genome 430 2.0 Array)   1455129_at (Mouse Genome 430 2.0 Array)   1455932_at (Mouse Genome 430 2.0 Array)   1458638_at (Mouse Genome 430 2.0 Array)   1459226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131814
Ensembl peptide - ENSMUSP00000154553
Ensembl peptide - ENSMUSP00000022865
Ensembl peptide - ENSMUSP00000126167
Ensembl peptide - ENSMUSP00000128288
Ensembl peptide - ENSMUSP00000129500
Ensembl peptide - ENSMUSP00000130190
NCBI entrez gene - 67154     See in Manteia.
MGI - MGI:1914404
RefSeq - XM_017316731
RefSeq - XM_006520150
RefSeq - XM_006520151
RefSeq - XM_006520152
RefSeq - XM_006520153
RefSeq - XM_017316728
RefSeq - XM_017316729
RefSeq - XM_017316730
RefSeq - NM_026002
RefSeq - XM_006520148
RefSeq - XM_006520149
RefSeq Peptide - NP_080278
swissprot - F6ZQL0
swissprot - F6ZSG0
swissprot - F6QHD1
swissprot - F6QFT1
swissprot - Q80WJ7
swissprot - E9PUX0
Ensembl - ENSMUSG00000022255
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtdhaENSDARG00000014159Danio rerio
 mtdhbENSDARG00000004939Danio rerio
 MTDHENSGALG00000034050Gallus gallus
 MTDHENSG00000147649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031402  Protein LYRIC


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0046581 intercellular canaliculus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(Wnt1)1Hev/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(MMTVneu)202Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(MMTVneu)202Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cep120tm1.2Blnw/Cep120tm1.2Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cep120tm1.2Blnw/Cep120tm1.2Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(Wnt1)1Hev/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev

Allelic Composition: MtdhGt(XB780)Byg/Mtdh+,Tg(Wnt1)1Hev/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(MMTVneu)202Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(Wnt1)1Hev/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev

Allelic Composition: MtdhGt(XB780)Byg/Mtdh+,Tg(Wnt1)1Hev/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev

Allelic Composition: MtdhGt(XB780)Byg/Mtdh+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTV-PyVT)634Mul

Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(MMTVneu)202Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul

 MP:0010282 decreased organ/body region tumor incidence "less than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011986 decreased macrophage proliferation "reduced ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0012419 decreased cardiovascular system tumor incidence "less than the expected number of tumors originating in the cardiovascular system in a given population in a given time period" [MGI:csmith]
Show

Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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