ENSG00000148334


Homo sapiens

Features
Gene ID: ENSG00000148334
  
Biological name :PTGES2
  
Synonyms : prostaglandin E synthase 2 / PTGES2 / Q9H7Z7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.11
Gene start: 128120693
Gene end: 128128462
  
Corresponding Affymetrix probe sets: 218083_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482913
Ensembl peptide - ENSP00000277462
Ensembl peptide - ENSP00000345341
Ensembl peptide - ENSP00000411378
NCBI entrez gene - 80142     See in Manteia.
OMIM - 608152
RefSeq - XM_011519051
RefSeq - NM_001256335
RefSeq - NM_025072
RefSeq - NM_198938
RefSeq - XM_005252239
RefSeq - XM_011519050
RefSeq Peptide - NP_945176
RefSeq Peptide - NP_001243264
RefSeq Peptide - NP_079348
swissprot - Q9H7Z7
swissprot - X6RJ95
swissprot - A6NHH0
Ensembl - ENSG00000148334
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgeslENSDARG00000068415Danio rerio
 ENSGALG00000033760Gallus gallus
 Ptges2ENSMUSG00000026820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR004045  Glutathione S-transferase, N-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR034334  Prostaglandin E synthase 2
 IPR034335  Prostaglandin E synthase 2, C-terminal
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0019371 cyclooxygenase pathway TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046903 secretion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0016829 lyase activity ISS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0043295 glutathione binding ISS
 molecular_functionGO:0050220 prostaglandin-E synthase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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