ENSMUSG00000026820


Mus musculus

Features
Gene ID: ENSMUSG00000026820
  
Biological name :Ptges2
  
Synonyms : Prostaglandin E synthase 2 Prostaglandin E synthase 2 truncated form / Ptges2 / Q8BWM0
  
Possible biological names infered from orthology : prostaglandin E synthase 2 / Q9H7Z7
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 32395896
Gene end: 32405772
  
Corresponding Affymetrix probe sets: 10471411 (MoGene1.0st)   1417591_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141638
Ensembl peptide - ENSMUSP00000028162
NCBI entrez gene - 96979     See in Manteia.
MGI - MGI:1917592
RefSeq - NM_133783
RefSeq Peptide - NP_598544
swissprot - A0A0A6YWP8
swissprot - Q8BWM0
Ensembl - ENSMUSG00000026820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgeslENSDARG00000068415Danio rerio
 ENSGALG00000033760Gallus gallus
 PTGES2ENSG00000148334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR004045  Glutathione S-transferase, N-terminal
 IPR034334  Prostaglandin E synthase 2
 IPR034335  Prostaglandin E synthase 2, C-terminal
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046903 secretion IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0016829 lyase activity ISS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0043295 glutathione binding ISS
 molecular_functionGO:0050220 prostaglandin-E synthase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: KitW-sh/KitW-sh
Genetic Background: involves: C57BL/6J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-sh/KitW-sh
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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