ENSG00000149084


Homo sapiens

Features
Gene ID: ENSG00000149084
  
Biological name :HSD17B12
  
Synonyms : HSD17B12 / hydroxysteroid 17-beta dehydrogenase 12 / Q53GQ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 43680558
Gene end: 43856617
  
Corresponding Affymetrix probe sets: 1554121_at (Human Genome U133 Plus 2.0 Array)   1554122_a_at (Human Genome U133 Plus 2.0 Array)   217869_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000278353
Ensembl peptide - ENSP00000490822
Ensembl peptide - ENSP00000490749
Ensembl peptide - ENSP00000490701
Ensembl peptide - ENSP00000490421
Ensembl peptide - ENSP00000490003
Ensembl peptide - ENSP00000436582
Ensembl peptide - ENSP00000379052
NCBI entrez gene - 51144     See in Manteia.
OMIM - 609574
RefSeq - XM_017017881
RefSeq - NM_016142
RefSeq - XM_011520156
RefSeq Peptide - NP_057226
swissprot - A0A1B0GU83
swissprot - A0A1B0GW85
swissprot - E9PI21
swissprot - Q53GQ0
swissprot - A0A1B0GW27
swissprot - A0A1B0GV93
swissprot - A0A1B0GVY6
Ensembl - ENSG00000149084
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6P3L6ENSDARG00000015709Danio rerio
 Q6QA33ENSDARG00000035872Danio rerio
 HSD17B12ENSGALG00000036787Gallus gallus
 O70503ENSMUSG00000027195Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P37058 / HSD17B3 / hydroxysteroid 17-beta dehydrogenase 3ENSG0000013094840
HSDL1 / Q3SXM5 / hydroxysteroid dehydrogenase like 1ENSG0000010316039


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006703 estrogen biosynthetic process IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity EXP
 molecular_functionGO:0102339 3-oxo-arachidoyl-CoA reductase activity IEA
 molecular_functionGO:0102340 3-oxo-behenoyl-CoA reductase activity IEA
 molecular_functionGO:0102341 3-oxo-lignoceroyl-CoA reductase activity IEA
 molecular_functionGO:0102342 3-oxo-cerotoyl-CoA reductase activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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