ENSG00000149357


Homo sapiens

Features
Gene ID: ENSG00000149357
  
Biological name :LAMTOR1
  
Synonyms : LAMTOR1 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 / Q6IAA8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 72085895
Gene end: 72103387
  
Corresponding Affymetrix probe sets: 223009_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438717
Ensembl peptide - ENSP00000439011
Ensembl peptide - ENSP00000439482
Ensembl peptide - ENSP00000440738
Ensembl peptide - ENSP00000445170
Ensembl peptide - ENSP00000278671
NCBI entrez gene - 55004     See in Manteia.
OMIM - 613510
RefSeq - NM_017907
RefSeq Peptide - NP_060377
swissprot - Q6IAA8
swissprot - F5GX19
swissprot - F5H267
swissprot - F5H3Y3
swissprot - F5H479
swissprot - H0YFI1
Ensembl - ENSG00000149357
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor1ENSDARG00000076464Danio rerio
 LAMTOR1ENSGALG00000035720Gallus gallus
 Q9CQ22ENSMUSG00000030842Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026310  LAMTOR1-like
 IPR028209  LAMTOR1/MEH1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IMP
 biological_processGO:0001919 regulation of receptor recycling IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0010872 regulation of cholesterol esterification IMP
 biological_processGO:0010874 regulation of cholesterol efflux IMP
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0060620 regulation of cholesterol import IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071986 Ragulator complex IEA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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