ENSMUSG00000030842


Mus musculus

Features
Gene ID: ENSMUSG00000030842
  
Biological name :Lamtor1
  
Synonyms : Lamtor1 / Q9CQ22 / Ragulator complex protein LAMTOR1
  
Possible biological names infered from orthology : late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 / Q6IAA8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 101905904
Gene end: 101926675
  
Corresponding Affymetrix probe sets: 10460765 (MoGene1.0st)   10555586 (MoGene1.0st)   1417463_a_at (Mouse Genome 430 2.0 Array)   1434124_x_at (Mouse Genome 430 2.0 Array)   1448718_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141774
Ensembl peptide - ENSMUSP00000033131
NCBI entrez gene - 66508     See in Manteia.
MGI - MGI:1913758
RefSeq - NM_025605
RefSeq Peptide - NP_079881
swissprot - A0A0A6YX02
swissprot - Q9CQ22
Ensembl - ENSMUSG00000030842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor1ENSDARG00000076464Danio rerio
 LAMTOR1ENSGALG00000035720Gallus gallus
 Q6IAA8ENSG00000149357Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026310  LAMTOR1-like
 IPR028209  LAMTOR1/MEH1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001919 regulation of receptor recycling IEA
 biological_processGO:0007032 endosome organization IMP
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0010872 regulation of cholesterol esterification IEA
 biological_processGO:0010874 regulation of cholesterol efflux IEA
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032418 lysosome localization IMP
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0060620 regulation of cholesterol import IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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