ENSG00000149809


Homo sapiens

Features
Gene ID: ENSG00000149809
  
Biological name :TM7SF2
  
Synonyms : O76062 / TM7SF2 / transmembrane 7 superfamily member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 65111845
Gene end: 65116384
  
Corresponding Affymetrix probe sets: 210130_s_at (Human Genome U133 Plus 2.0 Array)   227734_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431300
Ensembl peptide - ENSP00000431685
Ensembl peptide - ENSP00000436370
Ensembl peptide - ENSP00000436233
Ensembl peptide - ENSP00000435972
Ensembl peptide - ENSP00000435458
Ensembl peptide - ENSP00000434598
Ensembl peptide - ENSP00000434447
Ensembl peptide - ENSP00000433325
Ensembl peptide - ENSP00000433275
Ensembl peptide - ENSP00000432413
Ensembl peptide - ENSP00000432187
Ensembl peptide - ENSP00000432171
Ensembl peptide - ENSP00000279263
Ensembl peptide - ENSP00000329520
NCBI entrez gene - 7108     See in Manteia.
OMIM - 603414
RefSeq - NM_003273
RefSeq - NM_001277233
RefSeq Peptide - NP_001264162
RefSeq Peptide - NP_003264
swissprot - E9PQ50
swissprot - E9PP79
swissprot - E9PLS9
swissprot - E9PLL1
swissprot - E9PLI3
swissprot - E9PK81
swissprot - A0A024R577
swissprot - H0YCI8
swissprot - H0YDY5
swissprot - H0YEN6
swissprot - E9PS18
swissprot - O76062
swissprot - E9PS09
swissprot - E9PRQ1
swissprot - E9PQZ7
Ensembl - ENSG00000149809
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tm7sf2ENSDARG00000032816Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LBR / Q14739 / lamin B receptorENSG0000014381558
DHCR7 / Q9UBM7 / 7-dehydrocholesterol reductaseENSG0000017289338


Protein motifs (from Interpro)
Interpro ID Name
 IPR001171  Ergosterol biosynthesis ERG4/ERG24
 IPR018083  Sterol reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016126 sterol biosynthetic process IBA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IBA
 molecular_functionGO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0050613 delta14-sterol reductase activity TAS
 molecular_functionGO:0050661 NADP binding ISS


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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