ENSG00000150593


Homo sapiens

Features
Gene ID: ENSG00000150593
  
Biological name :PDCD4
  
Synonyms : PDCD4 / programmed cell death 4 / Q53EL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.2
Gene start: 110871795
Gene end: 110900006
  
Corresponding Affymetrix probe sets: 1557166_at (Human Genome U133 Plus 2.0 Array)   202730_s_at (Human Genome U133 Plus 2.0 Array)   202731_at (Human Genome U133 Plus 2.0 Array)   212593_s_at (Human Genome U133 Plus 2.0 Array)   212594_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000280154
Ensembl peptide - ENSP00000376816
Ensembl peptide - ENSP00000394668
NCBI entrez gene - 27250     See in Manteia.
OMIM - 608610
RefSeq - NM_014456
RefSeq - NM_001199492
RefSeq - NM_145341
RefSeq Peptide - NP_001186421
RefSeq Peptide - NP_055271
RefSeq Peptide - NP_663314
swissprot - Q53EL6
swissprot - Q5VZS7
Ensembl - ENSG00000150593
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd4bENSDARG00000041022Danio rerio
 PDCD4ENSGALG00000008700Gallus gallus
 Pdcd4ENSMUSG00000024975Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity ISS
 biological_processGO:0045786 negative regulation of cell cycle NAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0050729 positive regulation of inflammatory response ISS
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1904761 negative regulation of myofibroblast differentiation IMP
 biological_processGO:1905064 negative regulation of vascular smooth muscle cell differentiation IDA
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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