ENSMUSG00000024975


Mus musculus

Features
Gene ID: ENSMUSG00000024975
  
Biological name :Pdcd4
  
Synonyms : Pdcd4 / Programmed cell death protein 4 / Q61823
  
Possible biological names infered from orthology : programmed cell death 4 / Q53EL6
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53892231
Gene end: 53929861
  
Corresponding Affymetrix probe sets: 10463997 (MoGene1.0st)   1418840_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025931
Ensembl peptide - ENSMUSP00000073975
Ensembl peptide - ENSMUSP00000133135
NCBI entrez gene - 18569     See in Manteia.
MGI - MGI:107490
RefSeq - XM_006526762
RefSeq - NM_001168491
RefSeq - NM_001168492
RefSeq - NM_011050
RefSeq Peptide - NP_001161964
RefSeq Peptide - NP_035180
RefSeq Peptide - NP_001161963
swissprot - Q61823
Ensembl - ENSMUSG00000024975
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd4bENSDARG00000041022Danio rerio
 PDCD4ENSGALG00000008700Gallus gallus
 PDCD4ENSG00000150593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007569 cell aging ISS
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation ISO
 biological_processGO:1904761 negative regulation of myofibroblast differentiation ISO
 biological_processGO:1905064 negative regulation of vascular smooth muscle cell differentiation ISO
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process ISO
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0009737 prostate gland cysts "benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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