ENSG00000152527


Homo sapiens

Features
Gene ID: ENSG00000152527
  
Biological name :PLEKHH2
  
Synonyms : pleckstrin homology, MyTH4 and FERM domain containing H2 / PLEKHH2 / Q8IVE3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p21
Gene start: 43637273
Gene end: 43767987
  
Corresponding Affymetrix probe sets: 227148_at (Human Genome U133 Plus 2.0 Array)   239568_at (Human Genome U133 Plus 2.0 Array)   242436_at (Human Genome U133 Plus 2.0 Array)   243650_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430377
Ensembl peptide - ENSP00000282406
Ensembl peptide - ENSP00000427746
NCBI entrez gene - 130271     See in Manteia.
OMIM - 612723
RefSeq - XM_017003353
RefSeq - NM_172069
RefSeq - XM_017003351
RefSeq - XM_017003352
RefSeq Peptide - NP_742066
swissprot - Q8IVE3
swissprot - H0YBV1
swissprot - E5RGK1
Ensembl - ENSG00000152527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhh2ENSDARG00000040851Danio rerio
 PLEKHH2ENSGALG00000009947Gallus gallus
 Q8C115ENSMUSG00000040852Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ULM0 / PLEKHH1 / pleckstrin homology, MyTH4 and FERM domain containing H1ENSG0000005469047
Q7Z736 / PLEKHH3 / pleckstrin homology, MyTH4 and FERM domain containing H3ENSG0000006813711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030835 negative regulation of actin filament depolymerization IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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