ENSG00000153107


Homo sapiens

Features
Gene ID: ENSG00000153107
  
Biological name :ANAPC1
  
Synonyms : ANAPC1 / anaphase promoting complex subunit 1 / Q9H1A4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q13
Gene start: 111611639
Gene end: 111884690
  
Corresponding Affymetrix probe sets: 218575_at (Human Genome U133 Plus 2.0 Array)   229267_at (Human Genome U133 Plus 2.0 Array)   231973_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396695
Ensembl peptide - ENSP00000486322
Ensembl peptide - ENSP00000494863
Ensembl peptide - ENSP00000339109
Ensembl peptide - ENSP00000405375
NCBI entrez gene - 64682     See in Manteia.
OMIM - 608473
RefSeq - XM_017004715
RefSeq - XM_017004711
RefSeq - XM_017004712
RefSeq - XM_017004713
RefSeq - XM_017004714
RefSeq - NM_022662
RefSeq - XM_011511633
RefSeq - XM_011511634
RefSeq - XM_017004710
RefSeq Peptide - NP_073153
swissprot - H0Y564
swissprot - F8WAS1
swissprot - Q9H1A4
Ensembl - ENSG00000153107
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc1ENSDARG00000075687Danio rerio
 ENSGALG00000008254Gallus gallus
 Anapc1ENSMUSG00000014355Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024990  Anaphase-promoting complex subunit 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005829 cytosol TAS


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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