ENSG00000155561


Homo sapiens

Features
Gene ID: ENSG00000155561
  
Biological name :NUP205
  
Synonyms : nucleoporin 205 / NUP205 / Q92621
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q33
Gene start: 135557919
Gene end: 135648757
  
Corresponding Affymetrix probe sets: 212247_at (Human Genome U133 Plus 2.0 Array)   222382_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475318
Ensembl peptide - ENSP00000285968
Ensembl peptide - ENSP00000475665
Ensembl peptide - ENSP00000475877
Ensembl peptide - ENSP00000475539
NCBI entrez gene - 23165     See in Manteia.
OMIM - 614352
RefSeq - XM_005250235
RefSeq - NM_001329434
RefSeq - NM_015135
RefSeq Peptide - NP_055950
RefSeq Peptide - NP_001316363
swissprot - U3KPX2
swissprot - U3KQ97
swissprot - U3KQH5
swissprot - U3KQ47
swissprot - Q92621
Ensembl - ENSG00000155561
  
Related genetic diseases (OMIM): 616893 - ?Nephrotic syndrome, type 13, 616893
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup205ENSDARG00000042530Danio rerio
 ENSGALG00000011662Gallus gallus
 Nup205ENSMUSG00000038759Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR021827  Nucleoporin Nup186/Nup192/Nup205


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006409 tRNA export from nucleus TAS
 biological_processGO:0006913 nucleocytoplasmic transport TAS
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051292 nuclear pore complex assembly IMP
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034399 nuclear periphery IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0044611 nuclear pore inner ring IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017056 structural constituent of nuclear pore IMP


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
tRNA processing in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000097 Focal segmental glomerulosclerosis 
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 HP:0003774 End stage renal disease 
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 HP:0012588 Steroid-resistant nephrotic syndrome "A form of nephrotic syndrome that does not respond to treatment with steroid medication." [Eurenomics:ewuehl]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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