ENSG00000155629


Homo sapiens

Features
Gene ID: ENSG00000155629
  
Biological name :PIK3AP1
  
Synonyms : phosphoinositide-3-kinase adaptor protein 1 / PIK3AP1 / Q6ZUJ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 96593312
Gene end: 96720514
  
Corresponding Affymetrix probe sets: 1554508_at (Human Genome U133 Plus 2.0 Array)   226459_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339826
Ensembl peptide - ENSP00000360150
Ensembl peptide - ENSP00000360151
NCBI entrez gene - 118788     See in Manteia.
OMIM - 607942
RefSeq - XM_011539249
RefSeq - NM_152309
RefSeq - XM_005269499
RefSeq - XM_011539248
RefSeq - XM_005269498
RefSeq Peptide - NP_689522
swissprot - Q6ZUJ8
Ensembl - ENSG00000155629
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3ap1ENSDARG00000078285Danio rerio
 Q9DDT2ENSGALG00000005547Gallus gallus
 Q9EQ32ENSMUSG00000025017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BANK1 / Q8NDB2 / B cell scaffold protein with ankyrin repeats 1ENSG0000015306423


Protein motifs (from Interpro)
Interpro ID Name
 IPR017893  DBB domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0034134 toll-like receptor 2 signaling pathway ISS
 biological_processGO:0034142 toll-like receptor 4 signaling pathway ISS
 biological_processGO:0034154 toll-like receptor 7 signaling pathway ISS
 biological_processGO:0034162 toll-like receptor 9 signaling pathway ISS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding ISS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / reaction / complex






 

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