ENSG00000156427


Homo sapiens

Features
Gene ID: ENSG00000156427
  
Biological name :FGF18
  
Synonyms : FGF18 / fibroblast growth factor 18 / O76093
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.1
Gene start: 171419656
Gene end: 171457623
  
Corresponding Affymetrix probe sets: 206986_at (Human Genome U133 Plus 2.0 Array)   206987_x_at (Human Genome U133 Plus 2.0 Array)   211029_x_at (Human Genome U133 Plus 2.0 Array)   211485_s_at (Human Genome U133 Plus 2.0 Array)   214284_s_at (Human Genome U133 Plus 2.0 Array)   231382_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274625
NCBI entrez gene - 8817     See in Manteia.
OMIM - 603726
RefSeq - NM_003862
RefSeq Peptide - NP_003853
swissprot - O76093
Ensembl - ENSG00000156427
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf18aENSDARG00000088048Danio rerio
 fgf18bENSDARG00000043962Danio rerio
 FGF18ENSGALG00000002203Gallus gallus
 Fgf18ENSMUSG00000057967Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF17 / O60258 / fibroblast growth factor 17ENSG0000015881545
FGF8 / P55075 / fibroblast growth factor 8ENSG0000010783145


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028289  Fibroblast growth factor 18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001957 intramembranous ossification IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IGI
 biological_processGO:0045766 positive regulation of angiogenesis IGI
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding IDA
 molecular_functionGO:0005111 type 2 fibroblast growth factor receptor binding IDA
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 point mutants in cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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