ENSG00000158874


Homo sapiens

Features
Gene ID: ENSG00000158874
  
Biological name :APOA2
  
Synonyms : APOA2 / apolipoprotein A2 / P02652
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 161222292
Gene end: 161223631
  
Corresponding Affymetrix probe sets: 219465_at (Human Genome U133 Plus 2.0 Array)   219466_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477031
Ensembl peptide - ENSP00000477054
Ensembl peptide - ENSP00000477353
Ensembl peptide - ENSP00000356969
Ensembl peptide - ENSP00000476605
Ensembl peptide - ENSP00000476662
Ensembl peptide - ENSP00000476740
Ensembl peptide - ENSP00000476890
Ensembl peptide - ENSP00000476911
NCBI entrez gene - 336     See in Manteia.
OMIM - 107670
RefSeq - NM_001643
RefSeq Peptide - NP_001634
swissprot - Q76EI7
swissprot - V9GYC1
swissprot - V9GYE3
swissprot - V9GYG9
swissprot - V9GYM3
swissprot - D3DVG8
swissprot - V9GYS1
swissprot - P02652
Ensembl - ENSG00000158874
  
Related genetic diseases (OMIM): 107670 - Apolipoprotein A-II deficiency
  143890 - {Hypercholesterolemia, familial, modifier of}, 143890
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Apoa2ENSMUSG00000005681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006801  Apolipoprotein A-II (ApoA-II)
 IPR036172  Apolipoprotein A-II (ApoA-II) superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IDA
 biological_processGO:0006641 triglyceride metabolic process TAS
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IDA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IDA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010873 positive regulation of cholesterol esterification IDA
 biological_processGO:0010903 negative regulation of very-low-density lipoprotein particle remodeling IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0018158 protein oxidation IDA
 biological_processGO:0018206 peptidyl-methionine modification IDA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031647 regulation of protein stability IDA
 biological_processGO:0032375 negative regulation of cholesterol transport IMP
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IDA
 biological_processGO:0034370 triglyceride-rich lipoprotein particle remodeling IDA
 biological_processGO:0034371 chylomicron remodeling TAS
 biological_processGO:0034374 low-density lipoprotein particle remodeling IDA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IDA
 biological_processGO:0034378 chylomicron assembly TAS
 biological_processGO:0034380 high-density lipoprotein particle assembly IDA
 biological_processGO:0034384 high-density lipoprotein particle clearance IDA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0043691 reverse cholesterol transport IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IDA
 biological_processGO:0046340 diacylglycerol catabolic process IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0050996 positive regulation of lipid catabolic process IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060192 negative regulation of lipase activity IDA
 biological_processGO:0060621 negative regulation of cholesterol import IDA
 biological_processGO:0060695 negative regulation of cholesterol transporter activity IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IDA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IDA
 cellular_componentGO:0042627 chylomicron IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0005319 lipid transporter activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IDA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0034190 apolipoprotein receptor binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0055102 lipase inhibitor activity IDA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IDA
 molecular_functionGO:0070653 high-density lipoprotein particle receptor binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
Chylomicron remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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