ENSMUSG00000005681


Mus musculus

Features
Gene ID: ENSMUSG00000005681
  
Biological name :Apoa2
  
Synonyms : Apoa2 / Apolipoprotein A-II Proapolipoprotein A-II / P09813
  
Possible biological names infered from orthology : apolipoprotein A2 / P02652
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171225054
Gene end: 171226379
  
Corresponding Affymetrix probe sets: 10351546 (MoGene1.0st)   1417950_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005824
Ensembl peptide - ENSMUSP00000106951
Ensembl peptide - ENSMUSP00000106952
Ensembl peptide - ENSMUSP00000106953
NCBI entrez gene - 11807     See in Manteia.
MGI - MGI:88050
RefSeq - NM_001305550
RefSeq - NM_001305549
RefSeq - NM_001305585
RefSeq - NM_013474
RefSeq Peptide - NP_001292478
RefSeq Peptide - NP_001292479
RefSeq Peptide - NP_001292514
RefSeq Peptide - NP_038502
swissprot - P09813
Ensembl - ENSMUSG00000005681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOA2ENSG00000158874Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006801  Apolipoprotein A-II (ApoA-II)
 IPR036172  Apolipoprotein A-II (ApoA-II) superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response ISO
 biological_processGO:0006631 fatty acid metabolic process NAS
 biological_processGO:0006656 phosphatidylcholine biosynthetic process ISO
 biological_processGO:0006869 lipid transport IMP
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0009395 phospholipid catabolic process ISO
 biological_processGO:0009749 response to glucose ISO
 biological_processGO:0010873 positive regulation of cholesterol esterification ISO
 biological_processGO:0010903 negative regulation of very-low-density lipoprotein particle remodeling ISO
 biological_processGO:0015759 beta-glucoside transport NAS
 biological_processGO:0018158 protein oxidation ISO
 biological_processGO:0018206 peptidyl-methionine modification ISO
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IMP
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0032375 negative regulation of cholesterol transport ISO
 biological_processGO:0033344 cholesterol efflux ISO
 biological_processGO:0033700 phospholipid efflux ISO
 biological_processGO:0034370 triglyceride-rich lipoprotein particle remodeling ISO
 biological_processGO:0034374 low-density lipoprotein particle remodeling IBA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IBA
 biological_processGO:0034380 high-density lipoprotein particle assembly ISO
 biological_processGO:0034384 high-density lipoprotein particle clearance ISO
 biological_processGO:0042157 lipoprotein metabolic process IDA
 biological_processGO:0042632 cholesterol homeostasis ISO
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043691 reverse cholesterol transport ISO
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISS
 biological_processGO:0046340 diacylglycerol catabolic process ISO
 biological_processGO:0050995 negative regulation of lipid catabolic process ISO
 biological_processGO:0050996 positive regulation of lipid catabolic process ISO
 biological_processGO:0060192 negative regulation of lipase activity ISO
 biological_processGO:0060621 negative regulation of cholesterol import ISO
 biological_processGO:0060695 negative regulation of cholesterol transporter activity ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034361 very-low-density lipoprotein particle IBA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0034366 spherical high-density lipoprotein particle ISO
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0005319 lipid transporter activity ISO
 molecular_functionGO:0005543 phospholipid binding ISO
 molecular_functionGO:0008035 high-density lipoprotein particle binding IMP
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0031072 heat shock protein binding ISO
 molecular_functionGO:0031210 phosphatidylcholine binding IBA
 molecular_functionGO:0034190 apolipoprotein receptor binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0055102 lipase inhibitor activity ISO
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity ISO
 molecular_functionGO:0070653 high-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
Chylomicron remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

Allelic Composition: Apoa2tm1Bres/Apoa2tm1Bres,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres,Apoa2tm1Bres/Apoa2tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfr2tm1.1Nsub/Tfr2tm1.1Nsub
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Apoa2c/Apoa2c
Genetic Background: SAMP9

Allelic Composition: Apoa2b/Apoa2b
Genetic Background: SAMP6

Allelic Composition: Apoa2a/Apoa2a
Genetic Background: SAMP3

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

Allelic Composition: Apoa2tm1Bres/Apoa2tm1Bres,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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